With getting more and more friends on Facebook, I also get a whole bunch of them playing Mafia Wars, Farmville and all these other applications. And of course every day they have to share with me their latest score. I just found a good way how to stop getting these annoying updates in my news feed: In the entry of the application in your news feed, click on the application name (highlighted in the screenshot). This will lead you to the application page. On the application page you will see a link "Block Application" (Highlighted again). Click on it. Facebook will ask you to confirm your decision. Confirm to block it. Go back to your Facebook start page (news feed). All entries from this application will be gone!
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